Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 6/20 | 0.47 |
| ▸ | DPP4 | P27487 | 6/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 3/20 | 0.46 |
| ▸ | FAP | Q12884 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8191997 | 0.85 | DPP4 (0.61) | DPP4DPP8DPP7DPP9FAP | |
| SCHEMBL30050973 | 0.80 | ITGB1 (0.57) | ALDH1A1HSD17B10ACEACE2ITGB1 | |
| SCHEMBL29743032 | 0.75 | SLC6A2 (0.52) | ACEF2 | |
| SCHEMBL6302781 | 0.72 | ITGB1 (0.59) | ALDH1A1ITGB1ITGA4ITGB7 | |
| SCHEMBL9074016 | 0.72 | ACE (0.50) | ALDH1A1HSD17B10ACEATML3MBTL1 | |
| SCHEMBL9074014 | 0.72 | ACE (0.50) | ALDH1A1HSD17B10ACEATML3MBTL1 | |
| SCHEMBL30563223 | 0.71 | ACE (0.53) | ACEITGB1F2 | |
| SCHEMBL30862234 | 0.71 | SLC6A2 (0.54) | ACEITGB1 | |
| SCHEMBL10903563 | 0.71 | ACE2 (0.56) | L3MBTL1ACE2 | |
| SCHEMBL10903562 | 0.71 | ACE2 (0.56) | L3MBTL1ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6090786-A | HALOPYRROLE AMIDATED AMINO ACID USEFUL FOR INHIBITING SERINE PROTEASE ACTIVITY | FONDATECH BENELUX N.V. (BE) | 2000-07-18 | — | — | US | disclosed |
| EP-0764151-A2 | PURIFICATION OF SERINE PROTEASE AND SYNTHETIC INHIBITORS THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 1997-03-26 | — | — | EP | disclosed |
| WO-1995034538-A2 | PURIFICATION OF SERINE PROTEASES AND SYNTHETIC INHIBITORS THEREOF | UNIVERSITAIRE INSTELLING ANTWERPEN (BE) | 1995-12-21 | — | — | WO | disclosed |