Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693383 | 0.80 | TDP1 (0.49) | MAPTTDP1KDM4EFFAR4TSHR | |
| SCHEMBL8202046 | 0.80 | MAPT (0.42) | MAPTTDP1KDM4EFFAR4TSHR | |
| SCHEMBL8201828 | 0.79 | MAPT (0.43) | MAPTTDP1KDM4EFFAR4TSHR | |
| SCHEMBL8206250 | 0.79 | MAPT (0.47) | MAPTTDP1KDM4EPARP1TSHR | |
| SCHEMBL8204141 | 0.79 | HTR1B (0.43) | MAPTTDP1KDM4EFFAR4TSHR | |
| SCHEMBL8201916 | 0.78 | KMT2A (0.52) | MAPTTDP1TSHRRAB9ACYP2C9 | |
| SCHEMBL8202181 | 0.78 | TSHR (0.48) | MAPTTDP1KDM4ETSHRKMT2A | |
| SCHEMBL8202190 | 0.77 | MAPK1 (0.43) | MAPTTDP1KDM4ETSHRCYP3A4 | |
| SCHEMBL8202038 | 0.76 | MAPT (0.40) | MAPTTDP1KDM4ETSHRRAB9A | |
| SCHEMBL8206771 | 0.75 | MAPT (0.42) | MAPTTDP1TSHRRAB9ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013673-A | ADMINISTERING AN EFFECTIVE AMOUNT OF A NAPHTHYLOXYACETIC ACID DERIVATIVE OR NONTOXIC ACID ADDITION SALT OR HYDRATE TO TREAT OR PREVENT ABORTION, PAINE, DIARRHEA, CATHARTICS, ULCER, GASTRITIS, HYPERTENSION AND THROMBOSIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-01-11 | — | — | US | claimed |
| EP-0719760-B1 | Naphthalene derivatives and their use as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO (JP) | 1999-09-22 | — | — | EP | claimed |
| EP-0719760-A1 | Naphthyloxyacetic acid derivatives and their use as PGW2 agonists and antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-07-03 | — | — | EP | claimed |
| US-6013673-A | ADMINISTERING AN EFFECTIVE AMOUNT OF A NAPHTHYLOXYACETIC ACID DERIVATIVE OR NONTOXIC ACID ADDITION SALT OR HYDRATE TO TREAT OR PREVENT ABORTION, PAINE, DIARRHEA, CATHARTICS, ULCER, GASTRITIS, HYPERTENSION AND THROMBOSIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-01-11 | — | — | US | disclosed |
| EP-0719760-B1 | Naphthalene derivatives and their use as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO (JP) | 1999-09-22 | — | — | EP | disclosed |
| US-5753700-A | ANALGESICS; CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| EP-0719760-A1 | Naphthyloxyacetic acid derivatives and their use as PGW2 agonists and antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-07-03 | — | — | EP | disclosed |