Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206298 | 0.92 | ADRB3 (0.46) | TSHRMAPTTDP1KDM4ENPC1 | |
| SCHEMBL693383 | 0.90 | TDP1 (0.49) | TSHRMAPTTDP1KDM4EKMT2A | |
| SCHEMBL8206250 | 0.88 | MAPT (0.47) | TSHRMAPTTDP1KDM4EHTT | |
| SCHEMBL8201916 | 0.88 | KMT2A (0.52) | TSHRMAPTTDP1KMT2AMEN1 | |
| SCHEMBL8201828 | 0.84 | MAPT (0.43) | TSHRMAPTTDP1KDM4EKMT2A | |
| SCHEMBL8206771 | 0.84 | MAPT (0.42) | TSHRMAPTTDP1HTTLMNA | |
| SCHEMBL8204141 | 0.83 | HTR1B (0.43) | TSHRMAPTTDP1KDM4EKMT2A | |
| SCHEMBL8202046 | 0.83 | MAPT (0.42) | TSHRMAPTTDP1KDM4EKMT2A | |
| SCHEMBL8202557 | 0.83 | SLC6A9 (0.48) | MAPTTDP1KDM4EHTTKMT2A | |
| SCHEMBL8202795 | 0.82 | KDM4E (0.47) | MAPTTDP1KDM4ENPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6013673-A | ADMINISTERING AN EFFECTIVE AMOUNT OF A NAPHTHYLOXYACETIC ACID DERIVATIVE OR NONTOXIC ACID ADDITION SALT OR HYDRATE TO TREAT OR PREVENT ABORTION, PAINE, DIARRHEA, CATHARTICS, ULCER, GASTRITIS, HYPERTENSION AND THROMBOSIS | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-01-11 | — | — | US | disclosed |
| EP-0719760-B1 | Naphthalene derivatives and their use as PGE2 agonists and antagonists | ONO PHARMACEUTICAL CO (JP) | 1999-09-22 | — | — | EP | disclosed |
| EP-0719760-A1 | Naphthyloxyacetic acid derivatives and their use as PGW2 agonists and antagonists | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-07-03 | — | — | EP | disclosed |