Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.35 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195555 | 0.97 | KDM4E (0.40) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL8205833 | 0.90 | HDAC6 (0.47) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL27899511 | 0.89 | HDAC6 (0.50) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL3770556 | 0.89 | HDAC6 (0.50) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL27899512 | 0.87 | HDAC6 (0.47) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL3772867 | 0.87 | HDAC6 (0.47) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL8195548 | 0.85 | HDAC6 (0.37) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL8203124 | 0.80 | HDAC3 (0.34) | HDAC8HDAC3KDM4EALDH1A1KMT2A | |
| SCHEMBL3772418 | 0.79 | HDAC6 (0.59) | HDAC8HDAC3HDAC6KDM1AHDAC1 | |
| SCHEMBL13061218 | 0.78 | HDAC6 (0.47) | HDAC8HDAC3KDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053131-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |