Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195753 | 0.92 | HDAC3 (0.38) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8205561 | 0.91 | ITGB3 (0.37) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8207131 | 0.91 | ITGB3 (0.32) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL13007355 | 0.89 | HDAC3 (0.40) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8212256 | 0.87 | HDAC3 (0.41) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8195555 | 0.83 | KDM4E (0.40) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8206345 | 0.83 | HDAC6 (0.40) | HDAC3HDAC8KDM4EADRB2ADRB1 | |
| SCHEMBL13007366 | 0.83 | HDAC3 (0.36) | HDAC3HDAC8KDM4EMEN1ALDH1A1 | |
| SCHEMBL8204583 | 0.82 | OPRM1 (0.34) | HDAC3HDAC8HDAC6F10 | |
| SCHEMBL8195710 | 0.81 | HDAC6 (0.40) | HDAC3HDAC8KDM1AHDAC6FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053131-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |