Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.39 |
| ▸ | ITGAV | P06756 | 2/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3772418 | 0.91 | HDAC6 (0.59) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL8202073 | 0.90 | HDAC8 (0.40) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL8202871 | 0.89 | HDAC6 (0.43) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL8195555 | 0.89 | KDM4E (0.40) | HDAC6HDAC3HDAC8HDAC1ITGB3 | |
| SCHEMBL8205561 | 0.84 | ITGB3 (0.37) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL3778756 | 0.83 | HDAC6 (0.59) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL13061247 | 0.81 | HDAC6 (0.56) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL28780382 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL8203576 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC8HDAC1HDAC4 | |
| SCHEMBL28780389 | 0.80 | HDAC6 (0.54) | HDAC6HDAC3HDAC8HDAC1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008053131-A1 | HYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | CHROMA THERAPEUTICS LTD. (GB) | 2008-05-08 | — | — | WO | disclosed |