Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.40 |
| ▸ | AR | P10275 | 6/20 | 0.35 |
| ▸ | RARB | P10826 | 3/20 | 0.35 |
| ▸ | RARG | P13631 | 3/20 | 0.35 |
| ▸ | RARA | P10276 | 2/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 2/20 | 0.30 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8200212 | 0.86 | RXRA (0.42) | RXRARARBRARGRARARXRB | |
| SCHEMBL6678059 | 0.79 | RXRA (0.49) | RXRARARBRARGRARARXRB | |
| SCHEMBL3170254 | 0.75 | RXRA (0.44) | RXRARARBRARGRARAMEN1 | |
| SCHEMBL14492576 | 0.74 | RXRA (0.42) | RXRAARRARBRARGNOTUM | |
| SCHEMBL24809295 | 0.74 | RXRA (0.42) | RXRARARBRARGRARARXRB | |
| SCHEMBL29608697 | 0.73 | RXRA (0.45) | RXRARARBRARGRARARXRB | |
| SCHEMBL25129965 | 0.73 | RXRA (0.45) | RXRARARBRARGRARARXRB | |
| SCHEMBL2965251 | 0.71 | NOTUM (0.41) | NOTUMMEN1NPC1MAPTHTT | |
| SCHEMBL5846259 | 0.69 | RXRA (0.46) | RXRARARBRARGRARARXRB | |
| SCHEMBL31675854 | 0.69 | RXRA (0.42) | RXRARARBRARGRARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0997455-A1 | Restricted 9-cis retenoids | American Cyanamid Company (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5968908-A | Restricted 9-cis retinoids | AMERICAN CYANAMID COMPANY (US) | 1999-10-19 | — | — | US | disclosed |
| EP-0718285-A2 | Restricted 9-cis-retinoids | American Cyanamid Company (US) | 1996-06-26 | — | — | EP | disclosed |