Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13181748 | 1.00 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL13181761 | 0.92 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL15423889 | 0.92 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL5909599 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL5909621 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL5909602 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL5909604 | 0.83 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL13181763 | 0.80 | MAPT (0.45) | ALDH1A1MAPTPDK1MAPK1TSHR | |
| SCHEMBL6378758 | 0.78 | KMT2A (0.51) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL8344833 | 0.78 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063667-A1 | HETEROTRICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-05-29 | — | — | WO | disclosed |