Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5909599 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL5909621 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL5909602 | 1.00 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL6374894 | 0.92 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL6374900 | 0.92 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL6374885 | 0.92 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL6376449 | 0.85 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL6376451 | 0.85 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL13181748 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A | |
| SCHEMBL8203068 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPTKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237847-B1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER LAMBERT CO (US) | 2006-05-17 | — | — | EP | claimed |
| US-6864390-B2 | Method for the stereoselective synthesis of cyclic amino acids | WARNER-LAMBERT COMPANY (US) | 2005-03-08 | — | — | US | claimed |
| US-20030069438-A1 | Method for the stereoselective synthesis of cyclic amino acids | BRYANS JUSTIN STEPHEN (GB) | 2003-04-10 | — | — | US | claimed |
| EP-1237847-A1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 2002-09-11 | — | — | EP | claimed |
| WO-2001042190-A1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 2001-06-14 | — | — | WO | claimed |
| EP-1237847-B1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER LAMBERT CO (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20060084825-A1 | Novel method for the stereoselective synthesis of cyclic amino acids | WARNER-LAMBERT COMPANY (US) | 2006-04-20 | — | — | US | disclosed |
| US-6864390-B2 | Method for the stereoselective synthesis of cyclic amino acids | WARNER-LAMBERT COMPANY (US) | 2005-03-08 | — | — | US | disclosed |
| US-20030069438-A1 | Method for the stereoselective synthesis of cyclic amino acids | BRYANS JUSTIN STEPHEN (GB) | 2003-04-10 | — | — | US | disclosed |
| EP-1237847-A1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001042190-A1 | METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS | WARNER-LAMBERT COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030069438-A1 | Method for the stereoselective synthesis of cyclic amino acids | NPSR1, NTSR1, GAP43 | ALDH1A1 1702/4885SMN1; SMN2 750/4885MAPT 673/4885 |
| US-20060084825-A1 | Novel method for the stereoselective synthesis of cyclic amino acids | NPSR1, GAP43, NCSTN | ALDH1A1 2117/4885SMN1; SMN2 815/4885MAPT 569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.