Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13223285 | 0.72 | REN (0.39) | MAPTCTSLTP53AAK1KLK5 | |
| SCHEMBL20181256 | 0.70 | AAK1 (0.43) | MAPTCTSLSMN1; SMN2TP53AAK1 | |
| SCHEMBL10315020 | 0.69 | HTT (0.43) | MAPTHTTSMN1; SMN2TSHRCA1 | |
| SCHEMBL20181226 | 0.66 | AAK1 (0.55) | MAPTCTSLSMN1; SMN2TP53AAK1 | |
| SCHEMBL11193697 | 0.64 | CA1 (0.49) | MAPTSMN1; SMN2CA1CA2CA7 | |
| SCHEMBL26531724 | 0.64 | CA1 (0.53) | MAPTSMN1; SMN2CA1CA2CA7 | |
| SCHEMBL21442825 | 0.63 | MAPT (0.47) | MAPTCTSLSMN1; SMN2TP53AAK1 | |
| SCHEMBL20181112 | 0.63 | MAPT (0.47) | MAPTCTSLSMN1; SMN2TP53AAK1 | |
| SCHEMBL21442822 | 0.62 | CTSS (0.43) | MAPTCTSLTP53AAK1CTSS | |
| SCHEMBL20181458 | 0.62 | CTSS (0.43) | MAPTCTSLTP53AAK1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033389-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |