Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 10/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 10/20 | 0.40 |
| ▸ | CMA1 | P23946 | 2/20 | 0.36 |
| ▸ | CTRC | Q99895 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13435882 | 0.92 | F2 (0.40) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL6124816 | 0.91 | F2 (0.44) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL13436021 | 0.89 | F2 (0.43) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL6383995 | 0.89 | ITGB3 (0.39) | F2PRSS1ITGB3ITGA2BACE | |
| SCHEMBL7941871 | 0.88 | HDAC1 (0.35) | F2PRSS1ITGB3ITGA2BHDAC4 | |
| SCHEMBL6124828 | 0.88 | HDAC1 (0.35) | F2PRSS1ITGB3ITGA2BHDAC4 | |
| SCHEMBL12831782 | 0.87 | ITGB3 (0.40) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL6385317 | 0.87 | F2 (0.40) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL6124837 | 0.86 | F2 (0.40) | F2PRSS1ITGB3ITGA2BCMA1 | |
| SCHEMBL13339910 | 0.86 | USP2 (0.32) | F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1680137-B1 | Macrocyclic carboxylic acid and acylsulfonamide compound as inhibitor of HCV replication | HOFFMANN LA ROCHE (CH) | 2012-11-21 | — | — | EP | disclosed |
| WO-2009142842-A9 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2010-11-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| WO-2008064057-A1 | MACROCYCLIC PEPTIDES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008064061-A1 | MACROCYCLIC PEPTIDES AS HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008057873-A2 | INHIBITORS OF HEPATITIS C VIRUS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-15 | — | — | WO | disclosed |