Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | KLK8 | O60259 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLK1 | P06870 | 1/20 | 0.39 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29398620 | 0.87 | CTSL (0.51) | CTSLITGB3ITGA2BSIRT2 | |
| SCHEMBL7355009 | 0.87 | CTSL (0.51) | CTSLITGB3ITGA2BSIRT2 | |
| SCHEMBL6827318 | 0.84 | CTSL (0.39) | CTSL | |
| SCHEMBL8216035 | 0.83 | CTSL (0.49) | CTSLITGB3ITGA2BSIRT2 | |
| SCHEMBL8209997 | 0.82 | CTSL (0.39) | CTSLKLK8F2PLGPLAU | |
| SCHEMBL989683 | 0.81 | CCR6 (0.45) | PLAU | |
| SCHEMBL570911 | 0.80 | CCR6 (0.36) | CTSLPLAU | |
| SCHEMBL12503505 | 0.80 | CCR6 (0.36) | CTSLPLAU | |
| SCHEMBL7359299 | 0.78 | HTT (0.44) | CTSL | |
| SCHEMBL7355382 | 0.78 | HTT (0.43) | PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916888-A | Imidazo 1,5A!pyridine derived serine protease inhibitors | AKZO NOBEL, N.V. (NL) | 1999-06-29 | — | — | US | claimed |
| EP-0830371-B1 | IMIDAZO(1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | AKZO NOBEL NV (NL) | 2000-12-20 | — | — | EP | disclosed |
| US-5916888-A | Imidazo 1,5A!pyridine derived serine protease inhibitors | AKZO NOBEL, N.V. (NL) | 1999-06-29 | — | — | US | disclosed |
| EP-0830371-A1 | IMIDAZO 1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | Akzo Nobel N.V. (NL) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996038470-A1 | IMIDAZO[1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | AKZO NOBEL N.V. (NL) | 1996-12-05 | — | — | WO | disclosed |