Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 4/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | CTSS | P25774 | 3/20 | 0.42 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7355009 | 0.92 | CTSL (0.51) | CTSLSIRT2CTSSSIRT1ITGB3 | |
| SCHEMBL29398620 | 0.92 | CTSL (0.51) | CTSLSIRT2CTSSSIRT1ITGB3 | |
| SCHEMBL8203294 | 0.83 | CTSL (0.44) | CTSLSIRT2ITGB3ITGA2B | |
| SCHEMBL989683 | 0.82 | CCR6 (0.45) | — | |
| SCHEMBL6827318 | 0.80 | CTSL (0.39) | CTSL | |
| SCHEMBL7303916 | 0.80 | CTSL (0.52) | CTSLCTSSTACR1ITGB3ITGA2B | |
| SCHEMBL7359299 | 0.79 | HTT (0.44) | CTSL | |
| SCHEMBL7355382 | 0.79 | HTT (0.43) | — | |
| SCHEMBL29913526 | 0.79 | CTSL (0.53) | CTSLSIRT2CTSSTACR1SIRT1 | |
| SCHEMBL10908476 | 0.79 | CTSL (0.53) | CTSLSIRT2CTSSTACR1SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916888-A | Imidazo 1,5A!pyridine derived serine protease inhibitors | AKZO NOBEL, N.V. (NL) | 1999-06-29 | — | — | US | claimed |
| EP-0830371-B1 | IMIDAZO(1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | AKZO NOBEL NV (NL) | 2000-12-20 | — | — | EP | disclosed |
| US-5916888-A | Imidazo 1,5A!pyridine derived serine protease inhibitors | AKZO NOBEL, N.V. (NL) | 1999-06-29 | — | — | US | disclosed |
| EP-0830371-A1 | IMIDAZO 1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | Akzo Nobel N.V. (NL) | 1998-03-25 | — | — | EP | disclosed |
| WO-1996038470-A1 | IMIDAZO[1,5a]PYRIDINE DERIVED SERINE PROTEASE INHIBITORS | AKZO NOBEL N.V. (NL) | 1996-12-05 | — | — | WO | disclosed |