Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | GHSR | Q92847 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14154815 | 0.83 | MAPT (0.51) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL14114764 | 0.83 | POLB (0.54) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL3112806 | 0.81 | MAPT (0.57) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL295953 | 0.80 | NOTUM (0.61) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL13836239 | 0.78 | KMT2A (0.55) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL4881585 | 0.78 | CA12 (0.57) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL4341894 | 0.76 | NOTUM (0.78) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL7657790 | 0.75 | NOTUM (0.51) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL13485837 | 0.74 | MAPT (0.60) | MAPTKMT2AMEN1POLBTP53 | |
| SCHEMBL1661109 | 0.74 | MAPT (0.50) | MAPTKMT2AMEN1POLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |