Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL295953 | 0.91 | NOTUM (0.61) | NOTUMKMT2AMEN1MAPTKDM4E | |
| Hydrochloric Acid SCHEMBL7657795 | 0.85 | MAPT (0.47) | NOTUMKMT2AMEN1MAPTKDM4E | |
| SCHEMBL7008972 | 0.80 | NOTUM (0.56) | NOTUMKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL5962918 | 0.79 | NOTUM (0.55) | NOTUMMAPTKDM4EALDH1A1MAPK1 | |
| SCHEMBL14541930 | 0.78 | NOTUM (0.53) | NOTUMKMT2AMEN1MAPTKDM4E | |
| SCHEMBL7657600 | 0.78 | ALDH1A1 (0.49) | KMT2AMEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL9720036 | 0.76 | HTT (0.58) | KMT2AMEN1MAPTALDH1A1MAPK1 | |
| SCHEMBL433497 | 0.76 | HTT (0.58) | KMT2AMEN1MAPTALDH1A1MAPK1 | |
| SCHEMBL7657492 | 0.76 | CYP1A2 (0.49) | MAPTKDM4EALDH1A1 | |
| SCHEMBL3112806 | 0.76 | MAPT (0.57) | NOTUMKMT2AMEN1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6339092-B1 | FOR THERAPY RHEUMATOID ARTHRITIS, ARTHROSIS, TUMOUR INVASION AND GROWTH, INCLUDING MALIGNANT SPREAD AND THE FORMATION OF METASTASES, ULCERATIONS, ATHEROSCLEROSIS | ADIR ET COMPAGNIE (FR) | 2002-01-15 | — | — | US | disclosed |