Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | PRCP | P42785 | 4/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8202744 | 0.91 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2CCR1 | |
| SCHEMBL8200776 | 0.90 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2SIGMAR1 | |
| SCHEMBL8200335 | 0.90 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2SIGMAR1 | |
| SCHEMBL8200268 | 0.88 | HTR2C (0.46) | HTR2CPRCPMCHR1DRD2 | |
| SCHEMBL8204772 | 0.87 | HTR2C (0.50) | HTR2CHTR7MCHR1DRD2SIGMAR1 | |
| SCHEMBL8200324 | 0.87 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2 | |
| SCHEMBL8202809 | 0.87 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2SIGMAR1 | |
| SCHEMBL8198980 | 0.87 | HTR2C (0.55) | HTR2CHTR7MCHR1SLC18A3DRD2 | |
| SCHEMBL8588802 | 0.87 | HTR2C (0.48) | HTR2CMCHR1DRD2SIGMAR1 | |
| SCHEMBL8199999 | 0.87 | HTR2C (0.45) | HTR2CPRCPMCHR1DRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| US-6048877-A | Tetralone derivatives as antiarrhythmic agents | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-04-11 | — | — | US | disclosed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |