Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | USP5 | P45974 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199972 | 0.94 | HTR2C (0.46) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8200268 | 0.91 | HTR2C (0.46) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8200547 | 0.91 | HTR2C (0.48) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8198570 | 0.90 | HTR2C (0.47) | HTR2CDRD2OPRM1OPRK1SIGMAR1 | |
| SCHEMBL8202320 | 0.89 | USP5 (0.52) | HTR2CDRD2MCHR1USP5SIGMAR1 | |
| SCHEMBL8198781 | 0.89 | HTR2C (0.46) | HTR2CDRD2MCHR1DRD3SIGMAR1 | |
| SCHEMBL8201705 | 0.89 | HTR2C (0.46) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8199804 | 0.89 | HTR2C (0.49) | HTR2CDRD2OPRM1OPRK1MCHR1 | |
| SCHEMBL8203525 | 0.88 | SIGMAR1 (0.46) | HTR2CSIGMAR1TP53DRD4 | |
| SCHEMBL8202809 | 0.88 | HTR2C (0.45) | HTR2CDRD2OPRM1OPRK1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | claimed |
| WO-1998036749-A1 | TETRALONE DERIVATIVES AS ANTIARRHYTHMIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-08-27 | — | — | WO | disclosed |