Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 9/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | STAT1 | P42224 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213601 | 0.81 | GAA (0.41) | POLBSMN1; SMN2RAB9ALMNACYP1A2 | |
| SCHEMBL10415979 | 0.68 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL5420579 | 0.67 | POLB (0.51) | POLBSMN1; SMN2RAB9ALMNACYP1A2 | |
| SCHEMBL21059237 | 0.65 | CYP1A2 (0.61) | POLBSMN1; SMN2LMNACYP1A2CYP2C19 | |
| SCHEMBL2717245 | 0.64 | KCNN4 (0.38) | CYP1A2CYP2C19TSHRALDH1A1 | |
| SCHEMBL21059191 | 0.64 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL8800372 | 0.64 | CYP1A2 (0.47) | SMN1; SMN2RAB9ALMNACYP1A2CYP2C19 | |
| SCHEMBL9391326 | 0.64 | POLB (0.47) | POLBSMN1; SMN2RAB9ALMNACYP1A2 | |
| SCHEMBL3870702 | 0.64 | POLB (0.45) | POLBSMN1; SMN2RAB9ALMNACYP1A2 | |
| SCHEMBL9729337 | 0.63 | KCNN4 (0.39) | CYP1A2CYP2C19TSHRALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |