Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | STAT1 | P42224 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3004859 | 0.79 | MEN1 (0.47) | POLBGAARAB9ANPC1LMNA | |
| SCHEMBL3658399 | 0.75 | ITGB3 (0.53) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL290981 | 0.73 | TDP1 (0.50) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL2014294 | 0.72 | POLB (0.42) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL2364749 | 0.72 | POLB (0.46) | POLBSMN1; SMN2CYP1A2CYP2C19TDP1 | |
| Water SCHEMBL2946569 | 0.72 | TDP1 (0.49) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL21059262 | 0.72 | SMN1; SMN2 (0.66) | SMN1; SMN2CYP1A2CYP2C19TDP1TSHR | |
| SCHEMBL10440896 | 0.71 | POLB (0.48) | POLBGAASMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL5420579 | 0.71 | POLB (0.51) | POLBSMN1; SMN2CYP1A2CYP2C19TDP1 | |
| SCHEMBL31392231 | 0.71 | POLB (0.51) | POLBGAASMN1; SMN2CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064177-A2 | PROTEASE INHIBITORS | Ambrilia Biopharma Inc. (CA) | 2009-06-03 | — | — | EP | disclosed |
| WO-2008078200-A2 | PROTEASE INHIBITORS | AMBRILIA BIOPHARMA INC. (CA) | 2008-07-03 | — | — | WO | disclosed |