Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ESRRA | P11474 | 1/20 | 0.43 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9120657 | 0.87 | ESRRA (0.43) | CFTRMAPTTDP1MRGPRX4LMNA | |
| SCHEMBL16302025 | 0.85 | SCN8A (0.53) | CFTRMAPTTDP1MRGPRX4SCN8A | |
| SCHEMBL1365182 | 0.82 | CFTR (0.64) | CFTRMAPTTDP1MRGPRX4LMNA | |
| SCHEMBL18356892 | 0.82 | HTT (0.53) | MAPTLMNANPSR1ALDH1A1SMN1; SMN2 | |
| SCHEMBL13189341 | 0.80 | CFTR (0.63) | CFTRMAPTMRGPRX4LMNAALDH1A1 | |
| SCHEMBL1365207 | 0.79 | MAPT (0.71) | CFTRMAPTTDP1LMNAPOLB | |
| SCHEMBL31098226 | 0.78 | CFTR (0.60) | CFTRMAPTTDP1MRGPRX4ESRRA | |
| SCHEMBL9122911 | 0.76 | CCR1 (0.48) | CFTRMAPTTDP1MRGPRX4LMNA | |
| SCHEMBL9119563 | 0.76 | RXFP1 (0.49) | CFTRMAPTTDP1MRGPRX4LMNA | |
| SCHEMBL9118380 | 0.75 | GRIK1 (0.47) | MAPTTDP1LMNACCR1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343286-B1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | METHYLGENE INC (CA) | 2014-12-31 | — | — | EP | disclosed |
| EP-2489657-A2 | Inhibitors of histone deacetylase | MethylGene Inc. (CA) | 2012-08-22 | — | — | EP | disclosed |
| EP-2343286-A1 | Dibenzo[b,f][1,4]oxazepine derivatives as inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2011-07-13 | — | — | EP | disclosed |
| WO-2009137499-A1 | INHIBITORS OF HISTONE DEACETYLASE | ENVIVO PHARMACEUTICALS, INC. (US) | 2009-11-12 | — | — | WO | disclosed |
| WO-2008055068-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2008-05-08 | — | — | WO | disclosed |