Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.59 |
| ▸ | PGR | P06401 | 5/20 | 0.59 |
| ▸ | AR | P10275 | 4/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11870530 | 0.91 | NR3C1 (0.55) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL4734156 | 0.90 | NR3C1 (0.72) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL4734726 | 0.89 | NR3C1 (0.70) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL7080634 | 0.88 | NR3C1 (0.62) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8204278 | 0.87 | NR3C1 (0.60) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL11867392 | 0.87 | NR3C1 (0.79) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL11866793 | 0.86 | CYP3A4 (0.49) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL8502672 | 0.85 | NR3C1 (0.57) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL7905893 | 0.85 | NR3C1 (0.58) | NR3C1CYP3A4PGRARUSP2 | |
| SCHEMBL11682502 | 0.84 | NR3C1 (0.58) | NR3C1CYP3A4PGRARUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876393-B1 | 21-(2-OXO-TETRAHYDROFURAN)-THIO PREGNANE DERIVATIVES, A PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LTD (GB) | 2000-07-05 | — | — | EP | disclosed |
| US-6013244-A | AS ANTI-INFLAMMATORY OR ANTI-ALLERGIC AGENTS | GLAXO WELLCOME INC. (US) | 2000-01-11 | — | — | US | disclosed |
| US-3975378-A | ANTIINFLAMMATORY | SYNTEX (U.S.A.) INC. (US) | 1976-08-17 | — | — | US | disclosed |