Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.80 |
| ▸ | HPGD | P15428 | 8/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA4 | P22748 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL4603 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL28341718 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL10793800 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL455422 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL29888959 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL16116234 | 0.89 | KDM4E (1.00) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL27610421 | 0.89 | KDM4E (0.69) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL30376726 | 0.89 | KDM4E (0.68) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL30377096 | 0.89 | KDM4E (0.68) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 | |
| Salicylic Acid SCHEMBL11744965 | 0.88 | KDM4E (0.73) | KDM4EHPGDALDH1A1SMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159931-A | Lipid-modified insulin incorporated liposomes for selectively delivering cytotoxic agents to hepatoma cells | THE OHIO STATE UNIVERSITY (US) | 2000-12-12 | — | — | US | disclosed |