SCHEMBL8204449

SCHEMBL8204449

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Hf](C)(C)(=[SiH2])C1C(C)=Cc2c(-c3cccc4ccccc34)cccc21

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.33
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
ALDH1A1 P00352 5/20 0.33
CYP2A6 P11509 1/20 0.33
DHFR P00374 1/20 0.32
HPGD P15428 4/20 0.32
HSD17B10 Q99714 2/20 0.32
MAOA P21397 1/20 0.32
MAOB P27338 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 2/20 0.31
CYP11B2 P19099 1/20 0.31
TDP2 O95551 1/20 0.31
ALOX12 P18054 1/20 0.31
MAPK1 P28482 1/20 0.31
CASP3 P42574 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL818879 0.99 KDM4E (0.33) KDM4ECA12CA1CA2CA9
Bromide SCHEMBL8602733 0.97 KDM4E (0.32) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL817966 0.89
Hydrochloric Acid SCHEMBL6434572 0.86 ALDH1A1 (0.34) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL7939143 0.86 EDNRB (0.31) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL1685512 0.86
Hydrochloric Acid SCHEMBL7933105 0.85 KDM4E (0.33) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL7933052 0.84 EDNRB (0.32) KDM4ECA12CA1CA2CA9
SCHEMBL1048785 0.84 KDM4E (0.32) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL8359953 0.83 ALOX15 (0.33) KDM4EALDH1A1DHFRHPGDHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6136993-A CONTACTING IN GROUP 4 METAL COMPLEX OR ITS LEWIS BASE ADDUCT WITH METAL COMPLEX, RECOVERING RESULTING PRODUCT THE DOW CHEMICAL COMPANY (US) 2000-10-24 US claimed
US-6136993-A CONTACTING IN GROUP 4 METAL COMPLEX OR ITS LEWIS BASE ADDUCT WITH METAL COMPLEX, RECOVERING RESULTING PRODUCT THE DOW CHEMICAL COMPANY (US) 2000-10-24 US disclosed
US-6084115-A METAL DIENE-CONTAINING COMPLEXES BY REACTION WITH THE DIVALENT DERIVATIVE OF A BRIDGED BIDENTATE LIGAND; METALLOCENES; RACEMIC ISOMER USED TO PREPARE ISOTACTIC POLYOLEFINS, E.G., CRYSTALLINE POLYPROPYLENE. THE DOW CHEMICAL COMPANY (US) 2000-07-04 US disclosed