Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27433996 | 0.90 | TSHR (0.50) | LMNAALDH1A1SMN1; SMN2CYP2D6CYP1A2 | |
| Biphenyl SCHEMBL27525345 | 0.86 | TSHR (0.46) | LMNAALDH1A1SMN1; SMN2CYP2D6CYP1A2 | |
| SCHEMBL396482 | 0.86 | MEN1 (0.56) | LMNAALDH1A1PGRADRA2AADRA2B | |
| SCHEMBL8172221 | 0.80 | LMNA (0.59) | LMNAALDH1A1PGRADRA2AADRA2B | |
| SCHEMBL5696500 | 0.78 | LMNA (0.51) | LMNAALDH1A1PGRADRA2AADRA2B | |
| SCHEMBL23792374 | 0.77 | SLC6A4 (0.47) | ALDH1A1NPC1CHRM1TDP1SLC6A2 | |
| SCHEMBL2419442 | 0.76 | LMNA (0.53) | LMNAALDH1A1SMN1; SMN2CYP2D6CYP1A2 | |
| SCHEMBL8204476 | 0.76 | PDCD1 (0.46) | LMNAALDH1A1PGRADRA2AADRA2B | |
| SCHEMBL11509599 | 0.75 | HCAR2 (0.41) | LMNAALDH1A1SMN1; SMN2CHRM1TDP1 | |
| SCHEMBL330776 | 0.75 | TDP1 (0.56) | LMNAALDH1A1PGRADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000040-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002505-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-21 | — | — | WO | disclosed |