Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29193466 | 0.81 | PDCD1 (0.49) | PDCD1CD274ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL396482 | 0.79 | MEN1 (0.56) | ALDH1A1SMN1; SMN2LMNANPC1HTT | |
| SCHEMBL330776 | 0.78 | TDP1 (0.56) | ALDH1A1CYP3A4SMN1; SMN2LMNANPC1 | |
| SCHEMBL5562608 | 0.77 | AAK1 (0.46) | ALDH1A1CYP3A4LMNATSHRTDP1 | |
| SCHEMBL9293636 | 0.77 | ALDH1A1 (0.47) | PDCD1CD274ALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL8204480 | 0.76 | LMNA (0.59) | ALDH1A1CYP3A4SMN1; SMN2LMNANPC1 | |
| SCHEMBL330589 | 0.75 | L3MBTL1 (0.48) | ALDH1A1CYP3A4LMNANPC1HTT | |
| SCHEMBL6181797 | 0.74 | TDP1 (0.52) | ALDH1A1CYP3A4SMN1; SMN2LMNANPC1 | |
| SCHEMBL19695429 | 0.74 | TDP1 (0.52) | ALDH1A1CYP3A4SMN1; SMN2LMNANPC1 | |
| SCHEMBL187606 | 0.74 | TDP1 (0.52) | ALDH1A1CYP3A4SMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000040-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002505-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-21 | — | — | WO | disclosed |