Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23872474 | 0.77 | KDM4E (0.48) | SMN1; SMN2MAPTMAP2K4ALPLMAPK1 | |
| SCHEMBL23914767 | 0.76 | MAP2K4 (0.51) | SMN1; SMN2MAPTMAP2K4GSK3BCYP1A2 | |
| SCHEMBL8219414 | 0.75 | SMN1; SMN2 (0.49) | SMN1; SMN2MAPTALPLMAPK1PPARG | |
| SCHEMBL155393 | 0.71 | HSP90AB1 (0.46) | SMN1; SMN2MAPTHSP90AB1RXFP1 | |
| SCHEMBL29324357 | 0.71 | GPR17 (0.35) | SMN1; SMN2MAPTMAP2K4ALPLMAPK1 | |
| SCHEMBL21801325 | 0.71 | AGBL2 (0.49) | SMN1; SMN2MAPTMAPK1HSP90AB1 | |
| SCHEMBL23858844 | 0.69 | HCAR2 (0.44) | MAP2K4ALPLMAPK1GPR17 | |
| SCHEMBL30050008 | 0.69 | HCAR2 (0.44) | MAP2K4ALPLMAPK1GPR17 | |
| SCHEMBL4300704 | 0.69 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPT | |
| SCHEMBL14564361 | 0.69 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTMAP2K4GSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008040995-A9 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LTD (GB) | 2008-12-31 | — | — | WO | disclosed |
| WO-2008040995-A1 | INDAZOLES FOR USE AS DPP-IV INHIBITORS | PEAKDALE MOLECULAR LIMITED (GB) | 2008-04-10 | — | — | WO | disclosed |