SCHEMBL8205124

SCHEMBL8205124

CCCC1(c2ccccc2Cl)NC1(CCC)c1ccccc1Cl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN1 Q05586 4/20 0.37
GRIN2A Q12879 4/20 0.37
GRIN2D O15399 2/20 0.37
GRIN3B O60391 2/20 0.37
GRIN2B Q13224 2/20 0.37
GRIN2C Q14957 2/20 0.37
GRIN3A Q8TCU5 2/20 0.37
PDE7A Q13946 1/20 0.34
LMNA P02545 3/20 0.33
PGR P06401 1/20 0.33
TSHR P16473 1/20 0.33
TAAR1 Q96RJ0 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
HTR7 P34969 1/20 0.32
SLC6A4 P31645 2/20 0.32
KDM4E B2RXH2 1/20 0.32
OPRK1 P41145 1/20 0.32
OPRM1 P35372 1/20 0.32
CACNA1C Q13936 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8497537 0.84 GRIN1 (0.42) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B
SCHEMBL10877467 0.70 TAAR1 (0.41) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B
SCHEMBL5965970 0.69 PDE7A (0.42) PDE7ALMNAPGRKDM1A
SCHEMBL8204687 0.69 LMNA (0.41) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B
SCHEMBL8204306 0.68 SLC6A4 (0.36) LMNAPGRSLC6A4KDM4EHPGD
SCHEMBL8229529 0.67 SLC6A3 (0.40) PGRSLC6A4
1,2-Dichlorobenzene SCHEMBL27583458 0.66 TSHR (0.67) LMNATSHRTAAR1KDM4EHPGD
SCHEMBL805454 0.64 GRIN1 (0.50) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B
1,2-Dichlorobenzene SCHEMBL28151921 0.63 TSHR (0.71) LMNATSHRTAAR1SLC6A4
SCHEMBL10875357 0.61 GRIN1 (0.44) GRIN1GRIN2AGRIN2DGRIN3BGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6093851-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LTD. (JP) 2000-07-25 US disclosed
EP-0735018-B1 N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL CO (JP) 1999-07-21 EP disclosed
US-5739401-A N-(α-alkylbenzylidene)-α-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-04-14 US disclosed