Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SCN4A | P35499 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8213354 | 0.82 | KCNH2 (0.50) | SIGMAR1MEN1KMT2AKCNH2TSHR | |
| SCHEMBL8205331 | 0.80 | KCNH2 (0.52) | LMNAKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8214024 | 0.80 | SCN8A (0.47) | MEN1KMT2ALMNASCN8AAOC3 | |
| Hydrochloric Acid SCHEMBL8216124 | 0.79 | KCNH2 (0.51) | LMNAKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7697582 | 0.77 | KCNH2 (0.52) | SIGMAR1SCN4ALMNASCN1AKCNH2 | |
| SCHEMBL8203613 | 0.77 | HRH3 (0.43) | CYP1A2CYP3A4CYP2C9SCN8A | |
| SCHEMBL7695490 | 0.74 | SCN4A (0.48) | SIGMAR1SCN4ALMNASCN1AKCNH2 | |
| SCHEMBL7697606 | 0.74 | SCN4A (0.48) | SIGMAR1SCN4ALMNASCN1AKCNH2 | |
| SCHEMBL7695487 | 0.74 | SCN4A (0.48) | SIGMAR1SCN4ALMNASCN1AKCNH2 | |
| SCHEMBL9627913 | 0.71 | SIGMAR1 (0.66) | SIGMAR1KCNH2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037871-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | GYOGYSZERKUTATO INTEZET KFT. (HU) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999029655-A1 | NOVEL ANTIARRHYTHMIC COMPOUNDS | Gyógyszerkutató Intézet Kft. (HU) | 1999-06-17 | — | — | WO | disclosed |