Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3759037 | 0.80 | PARP1 (0.54) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL13547471 | 0.78 | GAA (0.44) | SMN1; SMN2MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL19662378 | 0.76 | SMN1; SMN2 (0.53) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL7501911 | 0.75 | ALDH1A1 (0.50) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL3759125 | 0.75 | SMN1; SMN2 (0.52) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL9528530 | 0.71 | PARP1 (0.54) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL8268335 | 0.71 | HDAC8 (0.50) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL31540297 | 0.71 | HDAC8 (0.71) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL82080 | 0.71 | HDAC8 (0.71) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 | |
| SCHEMBL14392730 | 0.71 | HDAC8 (0.50) | HDAC8HDAC6PARP1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |