Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 4/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.50 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.50 |
| ▸ | CHRNG | P07510 | 1/20 | 0.50 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.50 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | CHRND | Q07001 | 1/20 | 0.50 |
| ▸ | CHRNA2 | Q15822 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ECE2 | P0DPD6 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25951618 | 0.88 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL13561413 | 0.81 | ESR1 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL224375 | 0.81 | ESR1 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL29349682 | 0.81 | ESR1 (0.45) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL24609207 | 0.79 | CHRNB4 (0.43) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL14101255 | 0.79 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL24609198 | 0.78 | CHRNB4 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL24827106 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL13561410 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 | |
| SCHEMBL14003843 | 0.75 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100062046-A1 | POLYMORPHS OF NICOTINIC INTERMEDIATES | ALLEN DOUGLAS J M | 2010-03-11 | — | — | US | disclosed |
| US-20100062046-A1 | POLYMORPHS OF NICOTINIC INTERMEDIATES | ALLEN DOUGLAS J M | 2010-03-11 | — | — | US | disclosed |
| WO-2008060487-A2 | POLYMORPHS OF NICOTINIC INTERMEDIATES | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100062046-A1 | POLYMORPHS OF NICOTINIC INTERMEDIATES | NAPRT, NAMPT, NNMT | CHRNB2 22/4885CHRNA4 4/4885CHRNB4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.