Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 8/20 | 0.72 |
| ▸ | MMP2 | P08253 | 6/20 | 0.63 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | HPGD | P15428 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | MMP14 | P50281 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3058880 | 0.89 | MMP13 (0.61) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL8204629 | 0.86 | MMP13 (0.76) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL8209912 | 0.85 | MMP13 (0.83) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL8204370 | 0.85 | MMP13 (0.83) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL3064972 | 0.85 | MMP13 (0.56) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2407549 | 0.85 | MMP13 (0.61) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL6514040 | 0.84 | MMP13 (1.00) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL8209921 | 0.84 | MMP13 (0.81) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL24601450 | 0.84 | MMP13 (0.72) | MMP13MMP2RAB9AKDM4EALDH1A1 | |
| SCHEMBL5889575 | 0.84 | MMP13 (0.72) | MMP13MMP2RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359454-B1 | CC-1065 analogs having two CPI subunits | UPJOHN CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5541339-A | ANTITUMOR AGENTS | THE UPJOHN COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1990002746-A1 | NOVEL CC-1065 ANALOGS HAVING TWO CPI SUBUNITS | THE UPJOHN COMPANY (US) | 1990-03-22 | — | — | WO | disclosed |
| EP-0359454-A1 | Novel CC-1065 analogs having two CPI subunits | THE UPJOHN COMPANY (US) | 1990-03-21 | — | — | EP | disclosed |