Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.47 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.43 |
| ▸ | DPP4 | P27487 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13594616 | 0.83 | DPP7 (0.56) | DPP7DPP4NAMPTHDAC1NOTUM | |
| SCHEMBL8205782 | 0.81 | HDAC8 (0.40) | DPP7DPP8DPP9DPP4HDAC8 | |
| SCHEMBL29168673 | 0.74 | HDAC6 (0.56) | DPP7DPP8DPP9DPP4HDAC8 | |
| SCHEMBL1393814 | 0.74 | NR1H2 (0.50) | DPP7DPP8DPP9DPP4HDAC8 | |
| SCHEMBL14048143 | 0.74 | DPP8 (0.54) | DPP7DPP8DPP9DPP4NAMPT | |
| SCHEMBL6232215 | 0.74 | DPP7 (0.56) | DPP7DPP8DPP9DPP4NAMPT | |
| SCHEMBL6228669 | 0.73 | DPP7 (0.43) | DPP7DPP8DPP9DPP4HDAC8 | |
| SCHEMBL2930510 | 0.72 | ESR2 (0.54) | DPP7DPP4HDAC8HDAC6NAMPT | |
| SCHEMBL3773132 | 0.72 | ABHD6 (0.54) | ESR2HSP90AA1HSP90AB1 | |
| SCHEMBL25493196 | 0.70 | PDE2A (0.40) | NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033389-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |