Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.58 |
| ▸ | PDE4A | P27815 | 7/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.58 |
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | P4HB | P07237 | 1/20 | 0.52 |
| ▸ | PDE1A | P54750 | 1/20 | 0.51 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.51 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8769594 | 1.00 | PDE4B (0.58) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7149569 | 0.90 | PDE4B (0.69) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7149565 | 0.90 | PDE4B (0.69) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7318009 | 0.83 | PDE4D (0.57) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL8290599 | 0.83 | PDE4D (0.57) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL5309884 | 0.83 | PDE4D (0.67) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL8206531 | 0.82 | PDE4A (0.80) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL7447179 | 0.81 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7447175 | 0.81 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7326891 | 0.80 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640070-B1 | STYRYL DERIVATIVES, THEIR PREPARATION AND USE AS PDE-IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-09-10 | — | — | EP | claimed |