Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | VDR | P11473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8322191 | 1.00 | GAA (0.50) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL8187178 | 1.00 | GAA (0.50) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL28664196 | 0.86 | ALDH1A1 (0.58) | GAAALDH1A1CA9BCHEACHE | |
| SCHEMBL28510017 | 0.86 | EGFR (0.45) | GAACA2CA7ALDH1A1BCHE | |
| SCHEMBL22235831 | 0.86 | EGFR (0.45) | GAACA2CA7ALDH1A1BCHE | |
| SCHEMBL18706780 | 0.84 | EGFR (0.49) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL1904849 | 0.84 | CA2 (0.47) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL5748466 | 0.84 | CA2 (0.47) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL6934702 | 0.84 | GAA (0.48) | GAACA2CA7ALDH1A1CA9 | |
| SCHEMBL11784096 | 0.84 | BCHE (0.49) | GAACA2CA7ALDH1A1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071928-A | Spiro-piperidine derivatives and their use as therapeutic agents | MERCK SHARP & DOHME, LTD. (GB) | 2000-06-06 | — | — | US | disclosed |