Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.56 |
| ▸ | CA12 | O43570 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA7 | P43166 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 2/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.56 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.50 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | G6PD | P11413 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL28686792 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL10362316 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDCA12CA1 | |
| SCHEMBL221626 | 0.85 | TDP1 (0.52) | ALDH1A1KDM4EHPGDCA12CA1 | |
| SCHEMBL10434368 | 0.84 | KDM4E (0.50) | ALDH1A1KDM4EHPGDNAPRTCYP3A4 | |
| Hydrochloric Acid SCHEMBL7442929 | 0.83 | TDP1 (0.50) | ALDH1A1KDM4EHPGDCA12CA1 | |
| O-Tolylamine SCHEMBL7248185 | 0.81 | KMT2A (0.59) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Salicylic Acid SCHEMBL9634562 | 0.79 | ALDH1A1 (0.75) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Anthranilic Acid SCHEMBL28262622 | 0.79 | ALDH1A1 (0.75) | ALDH1A1KDM4EHPGDCA12CA1 | |
| Anthranilic Acid SCHEMBL31516788 | 0.79 | ALDH1A1 (0.75) | ALDH1A1KDM4EHPGDCA12CA1 | |
| SCHEMBL10387289 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4EHPGDNAPRTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6132743-A | COATING A ZINC OXIDE POWDER WITH AT LEAST ONE SILICONE COMPOUND IN A NONGASEOUS STATE AND FIRING THE COATED ZINC OXIDE POWDER IN AN OXIDIZING ATMOSPHERE AT A TEMPERATURE OF 600 TO 950 DEGREES C. | KANEBO, LTD. (JP) | 2000-10-17 | — | — | US | disclosed |