Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214405 | 0.90 | TSHR (0.46) | TSHRNAMPTMAPK1AURKBL3MBTL1 | |
| SCHEMBL8206681 | 0.85 | NAMPT (0.47) | TSHRNAMPTROCK2 | |
| SCHEMBL11926829 | 0.85 | PIK3CA (0.52) | TSHRNAMPTMAPK1AURKBPIK3CD | |
| SCHEMBL8218949 | 0.84 | TSHR (0.46) | TSHRNAMPTMAPK1AURKBPIK3CD | |
| SCHEMBL3599262 | 0.82 | PIK3CA (0.57) | PIK3CDPIK3CA | |
| SCHEMBL8218952 | 0.81 | NAMPT (0.46) | TSHRNAMPTMAPK1AURKBPIK3CD | |
| SCHEMBL11926847 | 0.81 | MTOR (0.42) | PIK3CDPIK3CAALDH1A1 | |
| SCHEMBL8218954 | 0.80 | NAMPT (0.53) | TSHRNAMPTPIK3CDPIK3CA | |
| SCHEMBL8097088 | 0.77 | TSHR (0.47) | TSHRNAMPTMAPK1AURKBPIK3CD | |
| SCHEMBL8215115 | 0.77 | PIK3CD (0.49) | TSHRNAMPTPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |