Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 6/20 | 0.54 |
| ▸ | NPFFR2 | Q9Y5X5 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3178014 | 0.87 | NPFFR1 (0.67) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL6123389 | 0.87 | NPFFR1 (0.67) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL11566400 | 0.86 | NPFFR1 (0.57) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL7834387 | 0.85 | ALDH1A1 (0.55) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL11569157 | 0.85 | UBE2M (0.54) | NPFFR1NPFFR2POLBALDH1A1FAAH | |
| SCHEMBL8173748 | 0.84 | ALDH1A1 (0.52) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL11564980 | 0.82 | NPFFR1 (0.65) | NPFFR1NPFFR2KMT2AALDH1A1FAAH | |
| SCHEMBL3479575 | 0.81 | BACE1 (0.48) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL3479578 | 0.81 | BACE1 (0.48) | NPFFR1NPFFR2KMT2APOLBALDH1A1 | |
| SCHEMBL20187134 | 0.80 | CYP2D6 (0.58) | NPFFR1NPFFR2KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030412-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | disclosed |