Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 3/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | F10 | P00742 | 3/20 | 0.36 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.35 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206727 | 1.00 | AGTR2 (0.44) | AGTR2MRGPRX4CA2CA1F2 | |
| SCHEMBL7247123 | 0.89 | AGTR2 (0.38) | AGTR2F2F10CYP26A1 | |
| SCHEMBL8212186 | 0.89 | FNTA (0.44) | AGTR2 | |
| SCHEMBL8212192 | 0.89 | FNTA (0.44) | AGTR2 | |
| SCHEMBL7247131 | 0.87 | AGTR2 (0.42) | AGTR2CYP26A1CYP24A1TBXAS1 | |
| SCHEMBL8383788 | 0.87 | FNTA (0.45) | AGTR2 | |
| SCHEMBL8205752 | 0.87 | FNTA (0.45) | AGTR2 | |
| SCHEMBL7706049 | 0.85 | AGTR2 (0.46) | AGTR2MRGPRX4CA2CA1CYP26A1 | |
| SCHEMBL7706060 | 0.85 | AGTR2 (0.46) | AGTR2MRGPRX4CA2CA1CYP26A1 | |
| SCHEMBL7241571 | 0.81 | TBXAS1 (0.47) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | claimed |
| EP-0975603-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998032741-A1 | INHIBITORS OF FARNESYL PROTEIN TRANSFERASE | ZENECA LIMITED (GB) | 1998-07-30 | — | — | WO | disclosed |