Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 6/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CPS1 | P31327 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212395 | 0.90 | ALDH1A1 (0.38) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL2931508 | 0.84 | POLB (0.38) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL2931509 | 0.83 | HTR2A (0.35) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL8205452 | 0.76 | MGLL (0.40) | ALDH1A1HPGDHTTHCRTR1HCRTR2 | |
| SCHEMBL2931793 | 0.73 | POLB (0.38) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL2931198 | 0.73 | HTR2A (0.38) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL2931197 | 0.73 | HTR2A (0.38) | ALDH1A1HPGDMEN1KMT2AHTT | |
| SCHEMBL3460327 | 0.67 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2927512 | 0.67 | CYP46A1 (0.41) | HCRTR1HCRTR2POLB | |
| SCHEMBL16277556 | 0.67 | HCRTR1 (0.47) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2008038251-A2 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-04-03 | — | — | WO | disclosed |