Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.59 |
| ▸ | PDE6C | P51160 | 1/20 | 0.52 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8206349 | 0.92 | PDE5A (0.58) | PDE5APDE6CPDE11A | |
| SCHEMBL7373885 | 0.91 | PDE5A (0.71) | PDE5APDE6CPDE11A | |
| SCHEMBL7376362 | 0.90 | PDE5A (0.66) | PDE5APDE6CPDE11A | |
| SCHEMBL7369832 | 0.87 | PDE5A (0.65) | PDE5APDE6CPDE11A | |
| SCHEMBL7377725 | 0.87 | PDE5A (0.68) | PDE5APDE6CPDE11A | |
| SCHEMBL8207695 | 0.87 | VCAM1 (0.59) | PDE5A | |
| SCHEMBL7372006 | 0.84 | PDE5A (0.51) | PDE5A | |
| SCHEMBL7407315 | 0.84 | PDE5A (0.83) | PDE5APDE6CPDE11A | |
| SCHEMBL7378244 | 0.83 | PDE5A (0.70) | PDE5APDE6CPDE11A | |
| SCHEMBL7371213 | 0.82 | PDE5A (0.64) | PDE5APDE6CPDE11A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |