Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GPR39 | O43194 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997515 | 0.76 | SCN9A (0.49) | KMT2ARIPK1 | |
| SCHEMBL4997504 | 0.76 | SCN9A (0.49) | KMT2ARIPK1 | |
| SCHEMBL4070879 | 0.76 | GAA (0.40) | LTA4HGAAMEN1KMT2ANPC1 | |
| SCHEMBL8893469 | 0.75 | CA12 (0.40) | MEN1KMT2A | |
| SCHEMBL8209635 | 0.73 | GAA (0.36) | LTA4HGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL5620305 | 0.73 | MEN1 (0.35) | GAAMEN1KMT2ABRPF1ALDH1A1 | |
| SCHEMBL5620313 | 0.73 | MEN1 (0.35) | GAAMEN1KMT2ABRPF1ALDH1A1 | |
| SCHEMBL4251386 | 0.73 | GAA (0.40) | LTA4HGAAMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL4993551 | 0.73 | GAA (0.35) | LTA4HGAAMEN1KMT2AALDH1A1 | |
| SCHEMBL8209791 | 0.72 | EPHX2 (0.42) | LTA4HGAAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008034735-A2 | 4-OXO-2,3,4,5-TETRAHYDRO-BENZO[B][1,4]DIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-03-27 | — | — | WO | disclosed |