Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.43 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28415218 | 0.81 | HSP90AA1 (0.39) | HSP90AA1HSP90B1HSP90AB1POLBRECQL | |
| SCHEMBL15530492 | 0.81 | HSP90AB1 (0.47) | HSP90AA1HSP90B1HSP90AB1KMT2APDGFRB | |
| SCHEMBL21591611 | 0.81 | HSP90AA1 (0.44) | HSP90AA1HSP90B1HSP90AB1POLBRECQL | |
| SCHEMBL1503881 | 0.81 | HSP90AA1 (0.36) | HSP90AA1HSP90B1HSP90AB1POLBRECQL | |
| SCHEMBL8203709 | 0.78 | HSP90AA1 (0.48) | HSP90AA1HSP90B1PDGFRB | |
| SCHEMBL1503877 | 0.78 | MEN1 (0.42) | HSP90AA1HSP90B1KMT2APDGFRB | |
| SCHEMBL2806625 | 0.78 | HSP90AA1 (0.48) | HSP90AA1HSP90B1HSP90AB1POLBRECQL | |
| SCHEMBL18818488 | 0.77 | DDB1 (0.53) | HSP90AA1HSP90B1HDAC1 | |
| SCHEMBL2806421 | 0.76 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1POLB | |
| SCHEMBL1503713 | 0.76 | HSP90AA1 (0.38) | HSP90AA1HSP90B1L3MBTL1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428762-B | Phthalazinone derivatives, preparation method and use thereof | 四川科伦博泰生物医药股份有限公司 | 2020-03-10 | — | — | CN | disclosed |
| WO-2008033389-A2 | MACROCYCLIC HCV INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2008-03-20 | — | — | WO | disclosed |