Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 3/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 3/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7138914 | 0.82 | KDM4E (0.40) | HRH1KDM4EALDH1A1CACNA1CHTR1A | |
| SCHEMBL7140680 | 0.81 | PTAFR (0.40) | HRH1ALDH1A1DRD2 | |
| SCHEMBL8207783 | 0.81 | HRH3 (0.46) | HRH1HTR1A | |
| SCHEMBL8208865 | 0.81 | HRH1 (0.52) | HRH1ALDH1A1HTR1ADRD2HTR2A | |
| SCHEMBL8212560 | 0.78 | HRH1 (0.40) | HRH1HTR1ADRD2HTR2A | |
| Water SCHEMBL6994538 | 0.74 | HRH1 (0.62) | HRH1SMN1; SMN2HTR2A | |
| SCHEMBL7893060 | 0.70 | HRH1 (0.44) | HRH1SMN1; SMN2KDM4EALDH1A1CACNA1C | |
| SCHEMBL6991699 | 0.70 | HRH1 (0.68) | HRH1HTR1ADRD2HTR2A | |
| Water SCHEMBL9383772 | 0.69 | HRH1 (0.57) | HRH1 | |
| SCHEMBL7895280 | 0.68 | HRH1 (0.42) | HRH1SMN1; SMN2KDM4EALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675889-B1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-07-05 | — | — | EP | disclosed |
| US-5595988-A | Triazolo(pyrrolo, thieno or furano)azepine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-01-21 | — | — | US | disclosed |