Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 5/20 | 0.38 |
| ▸ | DRD2 | P14416 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR2C | P28335 | 3/20 | 0.35 |
| ▸ | HTR2B | P41595 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | DRD3 | P35462 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8200822 | 0.81 | HRH1 (0.44) | HRH1CHRM2KCNH2HTR2AHTR2B | |
| SCHEMBL8207786 | 0.81 | HRH1 (0.42) | HRH1DRD2HTR1AHTR2AALDH1A1 | |
| SCHEMBL8207783 | 0.79 | HRH3 (0.46) | HRH1HTR1AADRA1AKCNH2SLC6A4 | |
| SCHEMBL7136207 | 0.79 | SETD7 (0.59) | HRH1SETD7DRD2DRD1DRD4 | |
| SCHEMBL8212560 | 0.78 | HRH1 (0.40) | HRH1DRD2HTR1AHTR2AOPRM1 | |
| SCHEMBL7140423 | 0.76 | SETD7 (0.43) | HRH1SETD7DRD2DRD1CHRM2 | |
| SCHEMBL7136262 | 0.75 | PTAFR (0.43) | HRH1SETD7DRD2DRD1CHRM2 | |
| SCHEMBL7140008 | 0.75 | DRD2 (0.43) | HRH1SETD7DRD2DRD1DRD4 | |
| SCHEMBL7174262 | 0.75 | PTAFR (0.43) | HRH1SETD7DRD2CHRM2HTR1A | |
| SCHEMBL9283218 | 0.75 | SETD7 (0.34) | HRH1SETD7DRD2CHRM2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675889-B1 | ANTIALLERGIC TRIAZOLO(PYRROLO, THIENO OR FURANO)AZEPINE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2000-07-05 | — | — | EP | claimed |