Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | DRD1 | P21728 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7893060 | 0.86 | HRH1 (0.44) | HRH1DRD3DRD2HTR2ATDP1 | |
| SCHEMBL9236878 | 0.83 | HRH1 (0.54) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9234670 | 0.83 | SIGMAR1 (0.41) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL7144620 | 0.83 | HRH1 (0.38) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9234626 | 0.82 | HRH1 (0.40) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9234345 | 0.80 | DRD2 (0.41) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9236256 | 0.78 | DRD2 (0.51) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9238456 | 0.76 | HRH1 (0.62) | HRH1DRD3DRD2HTR2ALMNA | |
| SCHEMBL9284502 | 0.72 | HRH1 (0.43) | HRH1DRD3DRD2HTR2ALMNA | |
| Water SCHEMBL7159274 | 0.71 | HRH1 (0.43) | HRH1DRD3DRD2HTR2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0708776-B1 | ANTIALLERGIC IMIDAZOAZEPINES | JANSSEN PHARMACEUTICA NV (BE) | 2001-01-03 | — | — | EP | disclosed |
| EP-0708776-A1 | ANTIALLERGIC IMIDAZOAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-05-01 | — | — | EP | disclosed |
| WO-1995002600-A1 | ANTIALLERGIC IMIDAZOAZEPINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-01-26 | — | — | WO | disclosed |