Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14263479 | 0.91 | MEN1 (0.43) | KMT2AMEN1SMN1; SMN2HRH3HDAC1 | |
| SCHEMBL8224879 | 0.91 | HDAC1 (0.44) | GPR119HDAC1HDAC6NPC1L1 | |
| SCHEMBL8227881 | 0.84 | HDAC1 (0.55) | GPR119KMT2AMEN1HDAC1HDAC6 | |
| SCHEMBL14263460 | 0.81 | GPR119 (0.44) | GPR119HDAC1HDAC6 | |
| SCHEMBL8208288 | 0.77 | HDAC1 (0.47) | GPR119HDAC1HDAC6 | |
| SCHEMBL8227841 | 0.76 | TRPV1 (0.55) | GPR119SMN1; SMN2NPC1L1 | |
| SCHEMBL8227883 | 0.75 | CACNA1H (0.47) | KMT2AMEN1SMN1; SMN2HDAC1HDAC6 | |
| SCHEMBL8218924 | 0.74 | HDAC1 (0.47) | GPR119HDAC1HDAC6 | |
| SCHEMBL8227850 | 0.74 | HDAC1 (0.45) | GPR119HDAC1HDAC6 | |
| SCHEMBL3985566 | 0.72 | GPR119 (0.45) | GPR119SMN1; SMN2HRH3HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033460-A2 | TREATING PAIN, DIABETES, AND LIPID METABOLISM DISORDERS | SCHERING CORPORATION (US) | 2008-03-20 | — | — | WO | disclosed |