Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732959 | 0.82 | CYP1A2 (0.48) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL19523166 | 0.80 | ALDH1A1 (0.49) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL7731192 | 0.80 | ALDH1A1 (0.47) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL9746670 | 0.79 | ALDH1A1 (0.49) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL7723426 | 0.79 | CYP1A2 (0.51) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL28182782 | 0.79 | L3MBTL1 (0.47) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL18138445 | 0.78 | CYP1A2 (0.51) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL3127219 | 0.77 | CYP1A2 (0.54) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL7733082 | 0.76 | CYP1A2 (0.51) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 | |
| SCHEMBL5609694 | 0.76 | CYP1A2 (0.49) | CYP1A2ALDH1A1TSHRHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071935-A | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0907649-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049700-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |