Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | GRM8 | O00222 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.43 |
| ▸ | ACP3 | P15309 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15675484 | 0.91 | TSHR (0.48) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL7009326 | 0.84 | TSHR (0.52) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL19339253 | 0.84 | L3MBTL1 (0.60) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL21201087 | 0.83 | TSHR (0.50) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL29867321 | 0.83 | TSHR (0.50) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL28490652 | 0.82 | L3MBTL1 (0.46) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL7732979 | 0.81 | LMNA (0.47) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL2744792 | 0.81 | POLB (0.37) | CYP3A4ALDH1A1KDM4E | |
| SCHEMBL28795751 | 0.80 | TSHR (0.53) | L3MBTL1MEN1HPGDKMT2ALMNA | |
| SCHEMBL11786819 | 0.78 | KMT2A (0.45) | L3MBTL1MEN1HPGDKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071935-A | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors | PFIZER INC. (US) | 2000-06-06 | — | — | US | disclosed |
| EP-0907649-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1999-04-14 | — | — | EP | disclosed |
| WO-1997049700-A1 | DERIVATIVES OF 2-(2-OXO-ETHYLIDENE)-IMIDAZOLIDIN-4-ONE AND THEIR USE AS FARNESYL PROTEIN TRANSFERASE INHIBITORS | PFIZER INC. (US) | 1997-12-31 | — | — | WO | disclosed |