Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208745 | 1.00 | LMNA (0.57) | LMNAALDH1A1THRBNPC1RAB9A | |
| SCHEMBL8219209 | 0.89 | NPC1 (0.60) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8219212 | 0.89 | NPC1 (0.60) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8209030 | 0.87 | NPC1 (0.53) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8220667 | 0.87 | NPC1 (0.53) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8220517 | 0.86 | NPC1 (0.52) | LMNAALDH1A1THRBNPC1RAB9A | |
| SCHEMBL8220519 | 0.86 | NPC1 (0.52) | LMNAALDH1A1THRBNPC1RAB9A | |
| SCHEMBL8211779 | 0.85 | NPC1 (0.54) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8211777 | 0.85 | NPC1 (0.54) | LMNAALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL8216223 | 0.84 | NPC1 (0.50) | LMNAALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046218-A | 4,5-DIMETHOXY-2-(3-OXO-3-PHENYL-1-PROPENYL)PYRIDINE USED TO CURE THE DISEASES PRODUCED BY CYTOKINE | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-04-04 | — | — | US | disclosed |
| EP-0838457-A1 | NOVEL PYRIDINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS ACTIVE INGREDIENT | SS Pharmaceutical Co., Ltd. (JP) | 1998-04-29 | — | — | EP | disclosed |