SCHEMBL8208975

SCHEMBL8208975

O=C(O)C1Cc2cc(Cl)c(Cl)cc2N1

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.56
MAPT P10636 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27343267 0.86 GAA (0.50) GAAMAPT
SCHEMBL27478709 0.81 GAA (0.45) GAAMAPT
SCHEMBL6164822 0.81 GAA (0.60) GAAMAPT
SCHEMBL6246219 0.81 GAA (0.60) GAAMAPT
SCHEMBL3256484 0.81 GAA (0.60) GAAMAPT
Hydrochloric Acid SCHEMBL11071035 0.80 GAA (0.58) GAAMAPT
Water SCHEMBL28741688 0.80 GAA (0.58) GAAMAPT
SCHEMBL5567865 0.80 PDE5A (0.39) GAAMAPT
SCHEMBL10276636 0.79 GAA (0.58) GAAMAPT
SCHEMBL29366763 0.79 GAA (0.58) GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1042288-A1 TRIPEPTIDYL PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2000-10-11 EP disclosed
WO-1999033801-A1 TRIPEPTIDYL PEPTIDASE INHIBITORS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 1999-07-08 WO disclosed